Mon 1st May 2017 – Dr Dave Christensen – “How to study Blindness in a petri dish – Stemcells and gene editing”
Dr Dave Christensen from the University of Southampton studies Age Related Macular Degeneration and similar inherited retinal diseases using induced pluripotent stem cells and gene editing. Dave has very kindly stepped up in at short notice to replace the planned speaker.He is also part of the team behind Bright Club Southampton, turning researchers into stand up comedians
Mon 3 April 2017 – Kris Strutt – “The Old Sarum Landscapes Project. Counterpoint Between Old Excavation Archives and New Survey Results”
The Old Sarum Landscapes Project has initiated a programme of archive research and fieldwork at the University of Southampton and the University of Swansea. Part of the project concerns new fieldwork at the site and in the surrounding landscape, and research in the excavation archives from the Society of Antiquaries excavations from 1910-1915, and the work of Musty and Rahtz in the 1950s. To date three seasons of archaeological survey has been conducted in and around the ancient monument of Old Sarum, complementing the ongoing documentary and archive research. This paper will present the latest results of the fieldwork, explaining the methodology that has been applied to date, and looking at some of the findings of the 2014-16 field seasons, including the results of geophysical survey in the outer bailey of Old Sarum, and the results of survey in the fields to the South and east of the monument, pointing to a long period of settlement in the Roman and medieval periods.
Mr Kristian Strutt is an Experimental Officer in Archaeology at the University of Southampton.
He specialises in archaeological mapping and geophysical survey, and is the Director of the Archaeological Prospection Services of Southampton unit, responsible for carrying out research survey work and applied archaeological geophysics. He previously worked as Camerone Assistant at the British School at Rome.
He has been involved in numerous research projects in Europe and further afield. These have included survey on the Portus Project, and surveys at Ostia Antica, Teano, Vignale, Capena, Vignale, Acilia and the Domus Aurea in Italy, surveys at Valencina de la Concepcion and the Guadiamar valley in Spain, and survey in Flanders, Northern France and Denmark. He has also been involved in research projects at Dura Europos in Syria, and archaeological survey at Schedia, Quesna and Kom el Ahmar in the Nile Delta, Egypt, and North Karnak in Upper Egypt, and directed the survey and excavation at Tidgrove Warren Farm in Hampshire, UK.
Mon 6th February 2017 – Frank Ratcliff & Catherine Mercer – Wessex AHSN – “The 100,000 genomes project; would you have your genome sequenced?”
The 100,000 Genomes Project will sequence 100,000 genomes from around 70,000 people. Participants are NHS patients with a rare disease, plus their families, and patients with cancer. Significantly, this is currently the largest national sequencing project of its kind in the world.
The aim is to create a new Genomic Medicine service for the NHS, transforming the way people are cared for. As a result of the project, genetic diagnoses will be made for some patients where this hadn’t previously been possible. In time, there is also the potential for new and more effective treatments for diseases with a genetic basis.
The project will also enable new medical research. Combining genomic sequence data with medical records is a ground-breaking resource. Researchers will study how best to use genomics in healthcare and how best to interpret the data to help patients. Using the 100,000 Genomes Project as a foundation, the aim is also to realise the potential of the UK genomics industry. This talk will explore the project, and ask the question; “Would you have your genome sequenced?” wessexahsn.org.uk/ @WessexAHSN
Mon 2nd January 2017 – Helena Lee – University of Southampton – “Targeting abnormal retinal development in early childhood: Can we treat visual impairment before it is a problem?”
In adults, optical coherence tomography (OCT) retinal imaging technology has revolutionised the diagnosis and treatment of degenerative retinal diseases. Infants and young children have been deprived of this technology until the recent development of hand-held OCT (HH-OCT) technology. Using HH-OCT we can monitor in vivo retinal development and investigate the natural history of retinal conditions such as colour blindness and albinism which are known to affect infants and young children, resulting in visual impairment in early childhood. Helena will be discussing her research and the implications for treating sight loss in infants and young children.
Dr Helena Lee is an Academic Clinical Lecturer in Ophthalmology at the University of Southampton and Southampton General Hospital. She is specialising in paediatric and neuro-ophthalmology, and her research interests lie in the area of normal and abnormal retinal development. She was awarded the 2015 Fight for Sight Award for her work describing normal in vivo foveal development in infants and young children using hand-held OCT. She has also investigated the effects of colour blindness and albinism on foveal development and is continuing to carry out research into retinal developmental disorders with the aim of identifying novel therapeutic targets and translating these into clinical practice.