2018 Archive

Mon 15th January 2018 – Prof Tim Underwood – From genome to clinic – tales from the oesophagus

Tim will illustrate how early detection of oesophageal cancer is enabled by genome sequencing, and how large-scale sequencing of patients is uncovering the biology behind this disease, enabling life-saving surgery and treatment to be targeted to the individual.

Tim Underwood is a surgeon at University Hospital Southampton with a special interest in oesophageal cancer and minimally invasive surgical techniques, and also Professor of Gastrointestinal Surgery at the University of Southampton.

Following a Medical Research Council (MRC) Clinician Scientist Fellowship, he became a Cancer Research UK & Royal College of Surgeons of England Advanced Clinician Scientist Fellow in April 2017.

Professor Underwood leads a programme of research studying the role of the tumour microenvironment in cancer development and progression. His team develop and apply advanced technologies to understand tumour complexity in oesophageal cancer including highly parallel genome-wide expression profiling of single cells using nanoliter droplets (DropSeq) and the generation of multicellular organoid models.

Professor Underwood is a member of the National Cancer Research Institute (NCRI) Upper GI Clinical Studies Group and he is a member of the Steering Committee of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium. He is a past Chairman of the Oesophageal Cancer Westminster Campaign and a trustee of Heartburn Cancer UK.